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Published November 2016 | public
Journal Article

Molecular Imaging of Brain Tumors Using Liposomal Contrast Agents and Nanoparticles

Abstract

The advent of genomic, proteomic, and high-throughput screening technologies has made available many new targets for brain tumor imaging; however, target availability and accessibility need to be carefully considered when designing imaging probes. Nanoparticles, although largely still only used in preclinical studies, are a versatile tool for targeted imaging of physiologic and molecular aspects of brain tumors through many clinically used modalities. Liposomes can be used to transport diverse payloads in vivo, including contrast agents and drugs, and may be functionalized to increase circulation half-life and achieve targeting specificity. Polymeric, gold, and iron oxide nanoparticles have been used for diverse applications in preclinical studies; however, the utility of other methods, such as quantum dots and self-assembling DNA molecules, is yet to be established.

Additional Information

© 2016 Elsevier Inc. Available online 14 September 2016.

Additional details

Created:
August 22, 2023
Modified:
October 23, 2023