Published October 27, 2008
| Published
Journal Article
Open
Realtime Photoacoustic Microscopy of Murine Cardiovascular Dynamics
- Creators
- Zemp, R. J.
- Song, L.
- Bitton, R.
- Shung, K. K.
-
Wang, L. V.
Chicago
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Abstract
Non-invasive visualization of cardiovascular dynamics in small animals is challenging due to their rapid heart-rates. We present a realtime photoacoustic imaging system consisting of a 30-MHz ultrasound array transducer, receive electronics, a high-repetition-rate laser, and a multicore-computer, and demonstrate its ability to image optically-absorbing structures of the beating hearts of young athymic nude mice at rates of ~50 frames per second with 100 µm×25 µm spatial resolution. To our knowledge this is the first report of realtime photoacoustic imaging of physiological dynamics.
Additional Information
© 2008 Optical Society of America. Received 10 Jun 2008; revised 8 Aug 2008; accepted 10 Aug 2008; published 24 Oct 2008. We thank the NIH transducer resource group for their work in fabrication of the high-frequency ultrasound transducer. This work was supported by NIH grants R01 EB000712 and R01 NS46214.Attached Files
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Additional details
- PMCID
- PMC2644743
- Eprint ID
- 70612
- Resolver ID
- CaltechAUTHORS:20160927-121109607
- NIH
- R01 EB000712
- NIH
- R01 NS46214
- Created
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2016-09-28Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field