Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent

Creators: Pramanik, Manojit; Swierczewska, Magdalena; Green, Danielle; Sitharaman, Balaji; Wang, Lihong V.

Abstract

We have developed a novel carbon nanotube-based contrast agent for both thermoacoustic and photoacoustic tomography. In comparison to deionized water, single-walled carbon nanotubes exhibited more than twofold signal enhancement for thermoacoustic tomography at 3GHz. In comparison to blood, they exhibited more than sixfold signal enhancement for photoacoustic tomography at 1064nm wavelength. The large contrast enhancement of single-walled carbon nanotubes was further corroborated by tissue phantom imaging studies.

Additional Information

© 2009 SPIE. Paper 09048R received Feb. 13, 2009; revised manuscript received Mar. 22, 2009; accepted for publication Mar. 26, 2009; published online Jun. 8, 2009. This work was sponsored by National Institutes of Health Grants No. R01 EB000712, No. R01 NS46214 (Bioengineering Research Partnerships), No. R01 EB008085, and No. U54 CA136398 (Network for Translational Research) (L.V.) and the Office of the Vice President of Research at Stony Brook University, Carol M. Baldwin fund (S.B.). L.W. has a financial interest in Endra, Inc., which, however, did not support this work. The authors thank Dr. Oleg Gang and Dr. Huming Xiong at the Center for Functional Nanomaterials, Brookhaven National Laboratory for access to the AFM, Tom Salagaj and Christopher Jensen at FirstNano/CVD Equipment Corporation for access to their CVD facilities, and Dr. Eunah Lee at Horiba JvonYvon, Edison, New Jersey, for the Raman spectroscopy measurements.

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