Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H_2 Adsorption and Drug Delivery
Abstract
The drug olsalazine (H_4olz) was employed as a ligand to synthesize a new series of mesoporous metal–organic frameworks that are expanded analogues of the well-known M_2(dobdc) materials (dobdc^4– = 2,5-dioxido-1,4-benzenedicarboxylate; M-MOF-74). The M_2(olz) frameworks (M = Mg, Fe, Co, Ni, and Zn) exhibit high surface areas with large hexagonal pore apertures that are approximately 27 Å in diameter. Variable temperature H_2 adsorption isotherms revealed strong adsorption at the open metal sites, and in situ infrared spectroscopy experiments on Mg_2(olz) and Ni_2(olz) were used to determine site-specific H_2 binding enthalpies. In addition to its capabilities for gas sorption, the highly biocompatible Mg_2(olz) framework was also evaluated as a platform for the delivery of olsalazine and other encapsulated therapeutics. The Mg_2(olz) material (86 wt % olsalazine) was shown to release the therapeutic linker through dissolution of the framework under simulated physiological conditions. Furthermore, Mg_2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of bioactive compounds. Under simulated physiological conditions, Mg_2(olz)(PEA)_2 disassembled to release PEA from the pores and olsalazine from the framework itself, demonstrating that multiple therapeutic components can be delivered together at different rates. The low toxicity, high surface areas, and coordinatively unsaturated metal sites make these M_2(olz) materials promising for a range of potential applications, including drug delivery in the treatment of gastrointestinal diseases.
Additional Information
© 2016 American Chemical Society. Received: April 6, 2016; Published: August 3, 2016. This research was supported through the Department of Energy, Office of Energy Efficiency and Renewable Energy, Fuel Cell Technologies Office under Grant DE-AC02-05CH11231. We thank the 17-BM staff at the Advanced Photon Source at Argonne National Laboratory for assisting with powder X-ray diffraction experiments. Use of the Advanced Photon Source at Argonne National Laboratory was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract DE-AC02-06CH11357. We gratefully acknowledge the NDSEG for providing fellowship support for D.J.L. and the NSF for supporting M.T.K., J.O., D.A.R., and J.A.M. We also thank M. I. Gonzalez for helpful discussions and Dr. K. R. Meihaus for editorial assistance. The authors declare no competing financial interest.Attached Files
Supplemental Material - ja6b03523_si_001.pdf
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Additional details
- Eprint ID
- 70380
- Resolver ID
- CaltechAUTHORS:20160915-140058475
- DE-AC02-05CH11231
- Department of Energy (DOE)
- DE-AC02-06CH11357
- Department of Energy (DOE)
- National Defense Science and Engineering Graduate (NDSEG) Fellowship
- NSF
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2016-09-28Created from EPrint's datestamp field
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2021-11-11Created from EPrint's last_modified field