Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging

Creators: Kim, Chulhong; Qin, Ruogu; Xu, Jeff S.; Wang, Lihong V.; Xu, Ronald

Abstract

We develop a novel dual-modal contrast agent—encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles—for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.

Additional Information

© 2010 SPIE. Paper 09505LR received Nov. 13, 2009; revised manuscript received Jan. 1, 2010; accepted for publication Jan. 6, 2010; published online Feb. 18, 2010. This work was supported in part by grants from the National Institutes of Health (R01 EB000712, R01 EB008085, R01 CA113453901, U54 CA136398—the Network for Translational Research, and 5P60 DK02057933 to Wang), and the Department of Defense Breast Cancer Research Program (W81XWH-07 to Xu). Wang has a financial interest in Microphotoacoustics, Incorporated, and in Endra, Incorporated, which, however, did not support this work.

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