Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo
Abstract
We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.
Additional Information
© 2012 SPIE. Paper 12080L received Feb. 6, 2012; revised manuscript received Apr. 4, 2012; accepted for publication Apr. 12, 2012; published online May 4, 2012. The authors appreciate Ms. Seema Dahlheimer's close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, R01 CA157277, and R01 CA159959. L. W. has financial interests in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.Attached Files
Published - JBO_17_5_050506.pdf
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Additional details
- PMCID
- PMC3382342
- Eprint ID
- 69687
- Resolver ID
- CaltechAUTHORS:20160817-081407589
- R01 EB000712
- NIH
- R01 EB008085
- NIH
- R01 CA134539
- NIH
- U54 CA136398
- NIH
- R01 EB010049
- NIH
- R01 CA157277
- NIH
- R01 CA159959
- NIH
- Created
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2016-08-17Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field