Ultrasound-modulated optical tomography at new depth
- Creators
- Lai, Puxiang
- Xu, Xiao
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Wang, Lihong V.
Abstract
Ultrasound-modulated optical tomography (UOT) has the potential to reveal optical contrast deep inside soft biological tissues at an ultrasonically determined spatial resolution. The optical imaging depth reported so far has, however, been limited, which prevents this technique from broader applications. Our latest experimental exploration has pushed UOT to an unprecedented imaging depth. We developed and optimized a UOT system employing a photorefractive crystal-based interferometer. A large aperture optical fiber bundle was used to enhance the efficiencies for diffuse light collection and photorefractive two-wave-mixing. Within the safety limits for both laser illumination and ultrasound modulation, the system has attained the ability to image through a tissue-mimicking phantom of 9.4 cm in thickness, which has never been reached previously by UOT.
Additional Information
© 2012 SPIE. Paper 12163 received Mar. 7, 2012; revised manuscript received Apr. 6, 2012; accepted for publication Apr. 10, 2012; published online Jun. 4, 2012. The authors thank Sandra Matteucci for editing the manuscript. This research is sponsored in part by National Academies Keck Futures Initiative grant IS 13 and National Institute of Health grants R01 EB000712 and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.Attached Files
Published - JBO_17_6_066006.pdf
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Additional details
- PMCID
- PMC3381033
- Eprint ID
- 69685
- Resolver ID
- CaltechAUTHORS:20160817-073054013
- National Academies Keck Futures Initiative
- IS 13
- NIH
- R01 EB000712
- NIH
- U54 CA136398
- Created
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2016-08-17Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field