Photoacoustic computed tomography correcting for heterogeneity and attenuation

Creators: Huang, Chao; Nie, Liming; Schoonover, Robert W.; Wang, Lihong V.; Anastasio, Mark A.

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Abstract

We report an investigation of image reconstruction in photoacoustic tomography for objects that possess heterogeneous material and acoustic attenuation distributions. When the object contains materials, such as bone and soft-tissue, that are modeled using power law attenuation models with distinct exponents, we demonstrate that the effects of acoustic attenuation due to the most strongly attenuating material can be compensated for if the attenuation of the other less attenuating material(s) are neglected. Experiments with phantom objects are presented to validated our findings.

Additional Information

© 2012 SPIE. Paper 11610SS received Oct. 18, 2011; revised manuscript received Jan. 20, 2012; accepted for publication Jan. 20, 2012; published online May 7, 2012. The authors acknowledge Brad Treeby and Ben Cox for helpful discussions regarding the k-Wave toolbox and Zijian Guo for useful discussions regarding the design of the experiment. Chao Huang, Robert W. Schoonover, and Mark A. Anastasio acknowledge support in part by NIH awards EB010049 and EB009715. Liming Nie and Lihong V. Wang acknowledge support by the NIH awards EB010049, CA134539, EB000712, CA136398, and EB008085. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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