A 25-mm diameter probe for photoacoustic and ultrasonic endoscopy

Creators: Yang, Joon-Mo; Chen, Ruimin; Favazza, Christopher; Yao, Junjie; Li, Chiye; Hu, Zhilin; Zhou, Qifa; Shung, K. Kirk; Wang, Lihong V.

Abstract

We have created a 2.5-mm outer diameter integrated photo-acoustic and ultrasonic mini-probe which can be inserted into a standard video endoscope's instrument channel. A small-diameter focused ultrasonic transducer made of PMN-PT provides adequate signal sensitivity, and enables miniaturization of the probe. Additionally, this new endoscopic probe utilizes the same scanning mirror and micromotor-based built-in actuator described in our previous reports; however, the length of the rigid distal section of the new probe has been further reduced to ~35 mm. This paper describes the technical details of the mini-probe and presents experimental results that both quantify the imaging performance and demonstrate its in vivo imaging capability, which suggests that it could work as a mini-probe for certain clinical applications.

Additional Information

© 2012 Optical Society of America. Received 2 Aug 2012; revised 15 Sep 2012; accepted 18 Sep 2012; published 4 Oct 2012. We thank Prof. James Ballard for his attentive reading of the manuscript, and Dr. Konstantin Maslov for useful discussions. This work was sponsored in part by National Institutes of Health grants R01 CA157277, R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA159959, and P41 EB002182. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. J.-M.Y. was supported in part by a Korea Research Foundation Grant funded by the Korean Government (KRF-2007-357-C00039).

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