Published February 2013
| Published
Journal Article
Open
Single-cell photoacoustic thermometry
Chicago
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Abstract
A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With three-seconds-per-frame imaging speed, a temperature resolution of 0.2°C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community.
Additional Information
© 2013 SPIE. Paper 12486L received Jul. 30, 2012; revised manuscript received Dec. 5, 2012; accepted for publication Jan. 2, 2013; published online Feb. 1, 2013. This work was sponsored by the National Institutes of Health (NIH) under grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, and R01 CA159959. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc.; however, neither provided support for this work.Attached Files
Published - JBO_18_2_026003.pdf
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JBO_18_2_026003.pdf
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Additional details
- PMCID
- PMC3556647
- Eprint ID
- 69488
- Resolver ID
- CaltechAUTHORS:20160805-154325044
- NIH
- R01 EB000712
- NIH
- R01 EB008085
- NIH
- R01 CA134539
- NIH
- U54 CA136398
- NIH
- R01 CA157277
- NIH
- R01 CA159959
- Created
-
2016-08-06Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field