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Published June 2016 | Published
Journal Article Open

Protein/peptide secondary structural mimics: design, characterization, and modulation of protein–protein interactions

Abstract

Protein–protein interactions (PPIs) play a critical role in many essential biological processes, and numerous diseases result from malfunctioning PPIs. The modulation of undesirable PPIs via synthetic chemical molecules has long been considered of medical importance, but still remains challenging. Thanks to the development of synthetic chemistry, chemists can synthesize protein/peptide secondary structure mimics to modulate the specific PPIs. This review discusses general aspects of novel artificial peptide secondary structure mimics for the modulation of PPIs, their therapeutic applications and future prospects.

Additional Information

© 2016 Royal Society of Chemistry. Received 30th May 2016. Accepted 13th June 2016. First published online 15 Jun 2016. The authors want to thank Tian Qiu, Xinlei Sheng and Geng Deng at Tsinghua University, Erol Can Vatansever from Texas A&M University, and Dr Reka Daniel-Weiner at Princeton Neuron Science Institution for their discussions or suggestions. This work was funded in part by the National Natural Science Foundation of China (grant number 21402206) and the Natural Science Foundation of Anhui Province (1508085QB30).

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August 20, 2023
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