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Published July 2014 | Published
Journal Article Open

Photoacoustic brain imaging: from microscopic to macroscopic scales

Abstract

Human brain mapping has become one of the most exciting contemporary research areas, with major breakthroughs expected in the coming decades. Modern brain imaging techniques have allowed neuroscientists to gather a wealth of anatomic and functional information about the brain. Among these techniques, by virtue of its rich optical absorption contrast, high spatial and temporal resolutions, and deep penetration, photoacoustic tomography (PAT) has attracted more and more attention, and is playing an increasingly important role in brain studies. In particular, PAT complements other brain imaging modalities by providing high-resolution functional and metabolic imaging. More importantly, PAT's unique scalability enables scrutinizing the brain at both microscopic and macroscopic scales, using the same imaging contrast. In this review, we present the state-of-the-art PAT techniques for brain imaging, summarize representative neuroscience applications, outline the technical challenges in translating PAT to human brain imaging, and envision potential technological deliverables.

Additional Information

© 2014 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 14018VSSR received Feb. 27, 2014; revised manuscript received Mar. 28, 2014; accepted for publication Mar. 31, 2014; published online May 28, 2014. The authors appreciate professor James Ballard's close reading of the paper, and Yu Zhang and professor Younan Xia (Georgia Institute of Technology) for providing the cultured neuron sample in Figs. 2(a) and 2(b). This work was sponsored by NIH Grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), R01 EB016963, R01 CA134539, R01 EB010049, R01 CA157277, and R01 CA159959. L.V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.

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August 22, 2023
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