In vivo optically encoded photoacoustic flowgraphy

Creators: Zhang, Ruiying; Wang, Lidai; Yao, Junjie; Yeh, Cheng-Hung; Wang, Lihong V.

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Abstract

We present an optically encoded photoacoustic (PA) flow imaging method based on optical-resolution PA microscopy. An intensity-modulated continuous-wave laser photothermally encodes the flowing medium, and a pulsed laser generates PA waves to image the encoded heat pattern. Flow speeds can be calculated by cross correlation. The method was validated in phantoms at flow speeds ranging from 0.23 to 11 mm/s. Venous blood flow speed in a mouse ear was also measured.

Additional Information

© 2014 Optical Society of America. Received March 17, 2014; accepted April 13, 2014; posted May 16, 2014 (Doc. ID 208239); published June 20, 2014. The authors would like to thank Dr. Konstantin Maslov for helpful discussions and experimental assistance. The authors would also like to thank Prof. James Ballard for his close reading of the manuscript. This research was supported by the National Institutes of Health Grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA134539, and R01 CA159959. L. V. W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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