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Published May 6, 2015 | public
Journal Article

Sputum Iron Levels During Cystic Fibrosis Pulmonary Exacerbation: A Longitudinal Study

Abstract

The airways of patients with cystic fibrosis are frequently colonized with bacteria, particularly Pseudomonas aeruginosa. Repeated pulmonary exacerbations contribute to decline in lung function. Iron is an important cofactor in bacterial growth and biofilm production in Pseudomonas aeruginosa. We demonstrated sputum ferrous iron and Pseudomonas bacterial burden are associated with worse lung function as measured by FEV_1 in cross-sectional studies. Ferrous iron constitutes a greater amount of total iron measured as lung function worsens. We hypothesized that sputum iron will decrease as lung function improves over the course of pulmonary exacerbation.

Additional Information

© 2015 American Thoracic Society. This abstract is funded by: Gardner Foundation Grant, Webb Foundation Grant, NIH and HHMI.

Additional details

Created:
August 22, 2023
Modified:
October 20, 2023