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Published January 21, 2013 | Accepted Version + Supplemental Material
Journal Article Open

Quantitative Analysis of the Fate of Gold Nanocages In Vitro and In Vivo after Uptake by U87-MG Tumor Cells

Abstract

Not always equal: When a mother cell that contains Au nanocages divides, the nanoparticles are unequally distributed between the two daughter cells. This unequal distribution of nanoparticles as well as their clearance from the cells (see picture) is quantitatively analyzed both in vitro and in vivo using two-photon microscopy and photoacoustic microscopy, respectively.

Additional Information

© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: October 8, 2012; Published online: December 6, 2012. This study was supported in part by a grant from NIH (R01 CA138527) and startup funds from Washington University in St. Louis (to Y.X.), and NIH Grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933 (to L.V.W.). Part of the research was conducted at the Alafi Neuroimaging Laboratory, the Hope Center for Neurological Disorders (NIH Neuroscience Blueprint Center Core Grant P30 NS057105).

Attached Files

Accepted Version - nihms496481.pdf

Supplemental Material - ange_201208096_sm_miscellaneous_information.pdf

Supplemental Material - ange_201208096_sm_movie_s1_day0.wmv

Supplemental Material - ange_201208096_sm_movie_s2_day2.wmv

Supplemental Material - ange_201208096_sm_movie_s3_day4.wmv

Supplemental Material - ange_201208096_sm_movie_s4_day6.wmv

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