Photoacoustic Tomography: Principles and Advances
- Creators
- Xia, Jun
- Yao, Junjie
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Wang, Lihong V.
Abstract
Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted, along with the most recent imaging results.
Additional Information
© 2014 EMW Publishing. Received 23 March 2014, Accepted 10 May 2014, Scheduled 15 May 2014. The authors appreciate Prof. James Ballard's help with editing the manuscript. This work was sponsored by the National Institutes of Health (NIH) grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), R01 EB016963, R01 CA157277, and R01 CA159959. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.Attached Files
Accepted Version - nihms610461.pdf
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Additional details
- PMCID
- PMC4311576
- Eprint ID
- 68563
- Resolver ID
- CaltechAUTHORS:20160622-083628913
- NIH
- DP1 EB016986
- NIH
- R01 CA186567
- NIH
- R01 EB016963
- NIH
- R01 CA157277
- NIH
- R01 CA159959
- Created
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2016-06-23Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field