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Published March 1965 | public
Journal Article

The Replication of Bacteriophage MS2: IV. RNA Components specifically associated with Infection

Abstract

Phage-specific RNA components synthesized in MS2-infected cells under conditions in which host RNA synthesis is suppressed have been characterized by ultracentrifugal analysis. In addition to the 27 s viral RNA, three specific components, designated as 20 s, 15 s and 6 s are described. Physical properties and enzymic resistance of the 15 s and 6 s forms suggest that these are, at least partially, double-stranded. The 20 s component appears to be a single-stranded RNA, of different configuration from the viral form.

Additional Information

© 1965 Elsevier Ltd. Received 26 October 1964. We are indebted to Dr Ray Valentine for valuable discussions and for assistance with the experiment with ultraviolet-irradiated cells. This research was supported in part by U.S. Public Health Service Grant RG6965.

Additional details

Created:
August 19, 2023
Modified:
October 19, 2023