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Published October 1964 | public
Journal Article

The Replication of Bacteriophage MS2 II. An in vivo Specificity for the Synthesis of Infective RNA

Abstract

Multiple infection with wild-type MS2 and a plaque-morphology mutant of MS2 is demonstrated. An infectivity assay for phage RNA is described and growth curves for intracellular infective RNA in MS2-infected cells are presented which demonstrate the presence of a pool of infective RNA prior to the appearance of progeny virus particles. Experiments are described which indicate that the synthetic system established in an MS2-infected cell will not be used to produce infective RNA of a genetically distinguishable superinfecting phage.

Additional Information

© 1964 Elsevier Ltd. Received 19 March 1964. This research was supported, in part, by a grant (RG-6965) from the U.S. Public Health Service. One of us (J. E. D.) was a postdoctoral fellow of the U.S. Public Health Service during part of this research period.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023