A Reversible Photochemical Alteration of Uracil and Uridine

Abstract

Various lines of evidence (1, 3, 4) have suggested that the primary effect of lethal and mutagenic doses of ultraviolet radiations upon living cells may be partially reversible, or at least compensated within the cell. In connection with a general study of the photochemistry of nucleic acid derivatives, we have discovered that, under certain conditions, the initial photodecomposition product of the pyrimidine, uracil, and the corresponding product of the ribose nucleotide, uridine, may spontaneously revert to the initial substances, uracil and uridine, respectively.

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