Published October 1957
| Published
Journal Article
Open
A Deoxyribonuclease from Calf Spleen: I Purification and Properties
- Creators
- Koerner, James F.
- Sinsheimer, Robert L.
Chicago
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Abstract
The deoxyribonucleases1 of animal tissues are of two types which are readily distinguishable by the conditions necessary for activity on their substrate, DNA. The pancreatic DNase, which has been crystallized by Kunitz (1), is active in neutral solution in the presence of magnesium or certain other divalent cations (2). The DN ase predominant in most other tissues is active at a lower pH, in the presence of adequate ionic strength, but does not specifically require divalent ions.
Additional Information
© 1957 American Society for Biochemistry and Molecular Biology. Received for publication, February 18, 1957. The research described in this paper was supported by a grant from the National Cancer Institute of the United States Public Health Service. Portions of this manuscript are taken from a dissertation submitted by J.F. Koerner in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Iowa State College.Attached Files
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Additional details
- Eprint ID
- 67468
- Resolver ID
- CaltechAUTHORS:20160531-074116499
- National Cancer Institute
- U.S. Public Health Service (USPHS)
- Created
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2016-05-31Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field