Stepwise Progression of Embryonic Patterning
- Creators
- Sandler, Jeremy E.
- Stathopoulos, Angelike
Abstract
It is long established that the graded distribution of Dorsal transcription factor influences spatial domains of gene expression along the dorsoventral (DV) axis of Drosophila melanogaster embryos. However, the more recent realization that Dorsal levels also change with time raises the question of whether these dynamics are instructive. An overview of DV axis patterning is provided, focusing on new insights identified through quantitative analysis of temporal changes in Dorsal target gene expression from one nuclear cycle to the next ('steps'). Possible roles for the stepwise progression of this patterning program are discussed including (i) tight temporal regulation of signaling pathway activation, (ii) control of gene expression cohorts, and (iii) ensuring the irreversibility of the patterning and cell fate specification process.
Additional Information
© 2016 Elsevier Ltd. Available online 24 May 2016. We thank members of the laboratory of A.S. for helpful discussions and comments on the manuscript. This work was funded by grant R01GM077668 from the National Institute of Health to A.S.Attached Files
Accepted Version - nihms782237.pdf
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Additional details
- PMCID
- PMC5065017
- Eprint ID
- 67372
- Resolver ID
- CaltechAUTHORS:20160526-073308501
- R01GM077668
- NIH
- Created
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2016-05-26Created from EPrint's datestamp field
- Updated
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2022-04-27Created from EPrint's last_modified field