Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published 1989 | public
Book Section - Chapter

Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA

Abstract

The design, synthesis, and DNA binding studies of a series of bis(netropsin)s linked by homologous polyether tethers has been undertaken. DNA affinity cleaving experiments show that one compound, bis(netropsin)-3,6,9,12,15-pentaoxahepta-decanediamine-EDTA:Fe(II) (1b:Fe(II)) is positively activated for specific DNA binding in the presence of Sr^(2+) or Ba^(2+) ions. The effects of linker structure, metal ion concentration, and DNA sequence on the metalloregulated binding are reported.

Additional Information

© 1989 Alan R. Liss. This work was supported by NIH and by NSF and Merck Sharpe & Dohme/ACS fellowships to JHG.

Additional details

Created:
August 19, 2023
Modified:
January 13, 2024