Published 2001
| public
Book Section - Chapter
The importance of β-alanine for recognition of the minor groove of DNA
- Creators
-
Dervan, Peter B.
- Urbach, Adam R.
Abstract
It is now well-recognized that there are two global motifs for targeting the minor groove of DNA based on analogs of the N-methylpyrrole-carboxamide ring of the natural product distamycin. There exist 1:1 and 2:1 stoichiometries with quite different rules of recognition and specificity. This ambiguity of sequence targeting depending on stoichiometry raises a serious design issue for the DNA recognition field.
Additional Information
© 2001 Verlag Helvetica Chimica Acta. We are grateful to the National Institutes of Health for support.Additional details
- Eprint ID
- 67188
- Resolver ID
- CaltechAUTHORS:20160519-124235592
- NIH
- Created
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2016-05-20Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field
- Series Name
- Essays in Contemporary Chemistry