Published January 1982
| public
Journal Article
Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)
- Creators
- Hertzberg, Robert P.
-
Dervan, Peter B.
Abstract
We report the synthesis of a simple bifunctional molecule, methidiumpropyl-EDTA (MPE) (1), which contains the DNA intercalator methidium covalently bound by a short hydrocarbon tether to the metal chelator EDT A. In the presence of ferrous ion and oxygen this reagent efficiently produces single-strand breaks and some double-strand breaks in double helical DNA.
Additional Information
© 1982 American Chemical Society. Received September 28, 1981. We are grateful to the National Institutes of Health for grant support (GM27681) and a National Research Service Award (GM 07616) to R.P.H. Contribution No. 6538 from Division of Chemistry and Chemical Engineering California Institute of Technology, Pasadena, California 91125.Additional details
- Eprint ID
- 67034
- Resolver ID
- CaltechAUTHORS:20160511-154909477
- GM-27681
- NIH
- GM-07616
- NIH Predoctoral Fellowship
- Created
-
2016-05-19Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field
- Other Numbering System Name
- Division of Chemistry and Chemical Engineering
- Other Numbering System Identifier
- 6358