Published July 1982
| public
Journal Article
Interhelical DNA-DNA crosslinking. Bis(monoazidomethidium)octaoxahexacosanediamine: a probe of packaged nucleic acid
- Creators
- Mitchell, Mark A.
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Dervan, Peter B.
Chicago
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Abstract
We describe the synthesis and purification of a new light-sensitive bifunctional molecule, bis(monoazidomethidium)octaoxahexacosanediamine (BAMO) (1), which contains all the criteria presumed necessary for an interhelical DNA-DNA cross-linker: a photoreactive DNA intercalator, monoazidomethidium, and a polyethyleneoxy chain sufficiently long (>25 Å) to span contiguous nucleic acid double helices. We also present evidence that BAMO efficiently cross-links packaged nucleic acid in intact bacteriophage λ.
Additional Information
© 1982 American Chemical Society. Received March 10, 1982. We are grateful to the National Institutes of Health (GM 22909) for generous support and to Professor Charles Cantor, Columbia University, for helpful discussions. Contribution No. 6584 from the Division of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125.Additional details
- Eprint ID
- 67032
- Resolver ID
- CaltechAUTHORS:20160511-154312167
- NIH
- GM-22909
- Created
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2016-05-19Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field
- Other Numbering System Name
- Division of Chemistry and Chemical Engineering
- Other Numbering System Identifier
- 6584