Published December 25, 1985
| public
Journal Article
Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin
- Creators
- Baker, Brenda F.
-
Dervan, Peter B.
Abstract
We report that N-bromoacetyldistamcyin (BD) which contains the electrophile bromoacetyl on the amino end of the tripeptide tris-N-methylpyrrolecarboxamide" cleaves a single adenine within a restriction fragment containing 167 base pairs of DNA after 5 h of reaction time at 37 °C followed by a depurination workup procedure.
Additional Information
© 1985 American Chemical Society. Received July 19, 1985. We are grateful to the National Institutes of Health (GM-27681) for support of this research.Additional details
- Eprint ID
- 67018
- Resolver ID
- CaltechAUTHORS:20160511-151543575
- GM-27681
- NIH
- Created
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2016-05-19Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field