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Published March 4, 1987 | public
Journal Article

Alteration of the sequence specificity of distamycin on DNA by replacement of an N-methylpyrrolecarboxamide with pyridine-2-carboxamide

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Abstract

Although there has been some encouraging success with regard to building synthetic molecules that bind large sequences of pure A,T-rich double-helical DNA, there has not been corresponding success in the development of well-understood G,C recognition. Progress in this area is an important component in an overall strategy of coupling G,C words and A,T words into sentences that uniquely recognize long sequences of right-handed DNA.

Additional Information

© 1987 American Chemical Society. Received September 8, 1986. We are grateful to the National Institutes of Health for research support (GM-27681) and to the National Science Foundation for a predoctoral fellowship to W.S.W.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023