Published April 12, 1989
| public
Journal Article
Triple helix formation by oligonucleotides on DNA extended to the physiological pH range
- Creators
- Povsic, Thomas J.
-
Dervan, Peter B.
Abstract
We report here that oligodeoxyribonucleotides which contain 5-bromouracil (Br^5U) and 5-methylcytosine (m^5C) bind duplex DNA at the same homopurine target sequence as their T/C analogues but with greater affinities and over an extended pH range. Oligonucleotides containing uracil (U) bind with lower affinity (Figure 1).
Additional Information
© 1989 American Chemical Society. Received September 16, 1988. We are grateful to the National Institutes of Health (GM 35724), Office of Naval Research for grant support (Contract N00014-88-K-0441) and to the National Science Foundation for a predoctoral fellowship to T.J.P.Additional details
- Eprint ID
- 66968
- Resolver ID
- CaltechAUTHORS:20160510-160429152
- GM-35724
- NIH
- N00014-88-K-0441
- Office of Naval Research (ONR)
- NSF Predoctoral Fellowship
- Created
-
2016-05-19Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field