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Published September 25, 1991 | Published
Journal Article Open

Effects of an abasic site on triple helix formation characterized by affinity cleaving

Abstract

The stability of triple helical complexes of pyrimidine oligodeoxyribonucleotides containing one abasic 1,2- dideoxy-D-ribose (ø) residue was examined by affinity cleaving. Within a pyrimidine third strand, the triplets ø·AT, ø·GC, ø·TA and ø·CG are significantly less stable than the triplets, T- AT, C + GC and GTA. The decrease in binding produced by an abasic residue is similar to that observed with imperfectly matched natural base triplets, with ø · AT and ø · GC being less stable than ø · TA and ø · CG triplets for the sequences studied.

Additional Information

© 1991 Oxford University Press. Received June 7, 1991; Revised and Accepted August 9, 1991. We are grateful for grant support from the National Institutes of Health, the Office of Naval Research, an unrestricted research grant from Burroughs-Wellcome, and a National Institutes of Health postdoctoral fellowship from the National Institutes of General Medical Science (D.A.H.).

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