Published September 25, 1991
| Published
Journal Article
Open
Effects of an abasic site on triple helix formation characterized by affinity cleaving
- Creators
- Horne, David A.
-
Dervan, Peter B.
Chicago
An error occurred while generating the citation.
Abstract
The stability of triple helical complexes of pyrimidine oligodeoxyribonucleotides containing one abasic 1,2- dideoxy-D-ribose (ø) residue was examined by affinity cleaving. Within a pyrimidine third strand, the triplets ø·AT, ø·GC, ø·TA and ø·CG are significantly less stable than the triplets, T- AT, C + GC and GTA. The decrease in binding produced by an abasic residue is similar to that observed with imperfectly matched natural base triplets, with ø · AT and ø · GC being less stable than ø · TA and ø · CG triplets for the sequences studied.
Additional Information
© 1991 Oxford University Press. Received June 7, 1991; Revised and Accepted August 9, 1991. We are grateful for grant support from the National Institutes of Health, the Office of Naval Research, an unrestricted research grant from Burroughs-Wellcome, and a National Institutes of Health postdoctoral fellowship from the National Institutes of General Medical Science (D.A.H.).Attached Files
Published - Nucl._Acids_Res.-1991-Horne-4963-5.pdf
Files
Nucl._Acids_Res.-1991-Horne-4963-5.pdf
Files
(1.8 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:0b10d0e17c5d2364d1e7182877f136e0
|
1.8 MB | Preview Download |
Additional details
- PMCID
- PMC328797
- Eprint ID
- 66954
- Resolver ID
- CaltechAUTHORS:20160510-145811847
- Office of Naval Research (ONR)
- Burroughs-Wellcome
- NIH Postdoctoral Fellowship
- Created
-
2016-05-19Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field