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Published March 1999 | public
Journal Article

Tandem Hairpin Motif for Recognition in the Minor Groove of DNA by Pyrrole–Imidazole Polyamides

Abstract

Linking hairpin recognition units "tail-to-turn" in the minor groove of DNA results in the extension of hairpin polyamide binding site size to 11 base pairs. A twelve-ring tandem hairpin (see diagram) binds its match DNA site at picomolar concentrations with unprecedented sequence specificity.

Additional Information

© 1999 Wiley-VCH Verlag GmbH, D-69451 Weinheim. Received: August 31, 1998. First published: 24 February 1999. We are grateful to the National Institutes of Health (GM-27681) for research support, the National Institutes of Health for a research service award to D.M.H., and the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B. We thank G.M. Hathaway for MALDITOF mass spectrometry.

Additional details

Created:
August 22, 2023
Modified:
October 18, 2023