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Published November 12, 2007 | Supplemental Material
Journal Article Open

Recognition of "mirror-image" DNA by small molecules

Abstract

May the force be with you: "Mirror-image" hairpin polyamides distinguish the L enantiomer of DNA (L-DNA) in the presence of natural DNA (D-DNA). This specificity is investigated by a molecular force balance at a single-molecule level. The "DNA balance" allows the measurement of rupture forces of match/mismatch diastereomeric complexes in a single experiment.

Additional Information

© 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: July 6, 2007; Revised: August 8, 2007; Published online: September 26, 2007. Support was provided by the National Institutes of Health, the Deutsche Forschungsgemeinschaft, and the Fonds der Chemischen Industrie. C.D. is grateful to the Alexander von Humboldt foundation for a postdoctoral fellowship. D.H. is grateful to the Elite Network of Bavaria (IDK-NBT) for a doctoral fellowship.

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