Published May 5, 1999
| public
Journal Article
Molecular Characterization and Phylogenetic Analysis of SpBMP5–7, a New Member of the TGF-β Superfamily Expressed in Sea Urchin Embryos
Chicago
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Abstract
TGF-β ligands are probably pan-bilaterian in phylogenetic distribution. The family appears to have diversified greatly with the evolution of the vertebrates, but only a few invertebrate deuterostome TGF-β molecules have so far been isolated. A search for members of this family expressed in sea urchin embryos, using canonical PCR primers, revealed a single-copy gene encoding a new TGF-β protein. The sequence which it encodes is closely related to those of vertebrate bone morphogenetic proteins (BMPs) 5-7. No additional TGF-β family members were uncovered other than univin, which had previously been reported.
Additional Information
© 1999 Society for Molecular Biology and Evolution. Accepted January 18, 1999. Stephen Palumbi, reviewing editor. This work was supported by NIH grant HD-05753 and NATO CRG 931023. M.R.P. was a fellow of Fundaciόn Rich. We are indebted to Markus Friedrich for assistance with the phylogenetic analyses and to R. Andrew Cameron for his careful review of a draft of this manuscript.Additional details
- Eprint ID
- 66056
- Resolver ID
- CaltechAUTHORS:20160411-144512549
- NIH
- HD-05753
- North Atlantic Treaty Organization (NATO)
- CRG 931023
- Created
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2016-04-12Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field