Bis(1-adamantyl)(2-morpholinophenyl)phosphine (Mor-DalPhos)
- Creators
- Lundgren, Rylan J.
- Other:
- Fuchs, Philip L.
Abstract
(ligand employed in transition metal-catalyzed reactions) Alternate Name: di(1-adamantyl)-2-morpholinophenylphosphine. Physical Data: mp 219–224 °C. Solubility: soluble in most polar organic solvents. Form Supplied in: White to pale yellow powder or crystals. Also commercially available as preformed Au-ligand complexes such as (MeCN)(Mor-Dalphos)Au(I) SbF_6 and [Mor-Dalphos]Au(I)Cl. Analysis of Reagent Purity: NMR, Elemental Analysis. Preparative Method: Pd-catalyzed cross-coupling of N-(2-bromophenyl)morpholine and diadamantyl phosphine. Handling, Storage, and Precautions: the phosphine is not particularly sensitive to air or moisture although precautions, such as storage under inert atmosphere in a cool place, should be taken during long-term storage. Bis(1-adamantyl)(2-morpholinophenyl)phosphine (Mor-DalPhos) is a phosphine ligand that has been employed in Pd-catalyzed cross-coupling reactions and Au-catalyzed hydroamination and [3+2] annulations. This ligand, when combined with an appropriate Pd-source, is particularly effective for promoting selective monoarylation processes between aryl electrophiles and nucleophiles such as ammonia, hydrazine, and acetone.
Additional Information
© 2001 John Wiley & Sons, Ltd. Published Online: 27 May 2014. Article includes InChi structural models.Attached Files
Published - rn01672.pdf
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Additional details
- Eprint ID
- 65885
- Resolver ID
- CaltechAUTHORS:20160404-092037342
- Created
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2016-04-18Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field