Published March 2016 | public
Conference Paper

Non-canonical amino acids as tools for protein medicinal chemistry

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Abstract

The engineering of therapeutic proteins has been advanced enormously by methods for site-directed mutagenesis. This lecture will describe an alternative, complementary approach, in which non- canonical amino acids are used to engineer protein-protein interactions, protein solvation and chain trajectory, with the objective of controlling the stability and pharmacokinetics of protein therapeutics.

Additional Information

© 2016 American Chemical Society.

Additional details

Created:
August 20, 2023
Modified:
October 18, 2023