Leukemia Inhibitory Factor Promotes Neural Stem Cell Self-Renewal in the Adult Brain
- Creators
- Bauer, Sylvian
- Patterson, Paul H.
Abstract
Although neural stem cells (NSCs) persist in various areas of the adult brain, their contribution to brain repair after injury is very limited. Treatment with exogenous growth factors can mitigate this limitation, suggesting that the brain environment is normally deficient in permissive cues and that it may be possible to stimulate the latent regenerative potential of endogenous progenitors with appropriate signals. We analyzed the effects of overexpressing the cytokine leukemia inhibitory factor (LIF) on adult neurogenesis in the normal brain. We found that LIF reduces neurogenesis in the olfactory bulb and subventricular zone by acting directly on NSCs. LIF appears to promote NSC self-renewal, preventing the emergence of more differentiated cell types. This ultimately leads to an expansion of the NSC pool. Our results have implications for the development of therapeutic strategies for brain repair and suggest that LIF may be useful, in combination with other factors, in promoting regeneration in the adult brain.
Additional Information
© 2006 Society for Neuroscience. For the first six months after publication SfN's license will be exclusive. Beginning six months after publication the Work will be made freely available to the public on SfN's website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received July 18, 2006; revised Oct. 15, 2006; accepted Oct. 17, 2006. This work was supported by a fellowship from The John Douglas French Alzheimer's Foundation (S.B.) and by grants from the National Institute of Neurological Disorders and Stroke and the McGrath Foundation (P.H.P.). We are grateful to D. McDowell, B. Kennedy, and members of the California Institute of Technology Office of Laboratory Animal Resources for their excellent assistance. We also thank F. H. Gage (The Salk Institute, San Diego, CA) for the generous gift of the retroviral plasmids and N. L. Nadon (National Institute on Aging, Bethesda, MD) for the 16-month-old C57BL/6J mice. We are grateful to C. Charrier for help with the neurosphere culture and to A. Lukaszewicz for critical reading of this manuscript.Attached Files
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Additional details
- PMCID
- PMC6674883
- Eprint ID
- 64465
- Resolver ID
- CaltechAUTHORS:20160212-095839863
- John Douglas French Alzheimer's Foundation
- National Institute of Neurological Disorders and Stroke (NINDS)
- McGrath Foundation
- Created
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2016-02-19Created from EPrint's datestamp field
- Updated
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2022-03-04Created from EPrint's last_modified field