Metabolic regulation of mitochondrial dynamics

Creators: Mishra, Prashant; Chan, David C.

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Abstract

Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.

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© 2016 Mishra and Chan This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses by-nc-sa/3.0/). Submitted: 9 November 2015; Accepted: 6 January 2016; Published February 8, 2016. This work was supported by grants from the National Institutes of Health (GM110039) and the Muscular Dystrophy Association. The authors declare no competing financial interests.

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