Published September 2004
| public
Journal Article
Gene-Regulatory Interactions in Neural Crest Evolution and Development
Chicago
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Abstract
In this review, we outline the gene-regulatory interactions driving neural crest development and compare these to a hypothetical network operating in the embryonic ectoderm of the cephalochordate amphioxus. While the early stages of ectodermal patterning appear conserved between amphioxus and vertebrates, later activation of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty. This difference may reflect co-option of genetic pathways which conferred novel properties upon the evolving vertebrate neural plate border, potentiating the evolution of definitive neural crest.
Additional Information
© 2004 Cell Press. The authors wish to express their sincerest thanks to Robb Krumlauf, Eric Davidson, Ellen Rothenberg, and Scott Fraser for their invaluable inspiration and feedback, as well as to the anonymous reviewers whose thoughtful suggestions greatly improved the quality of this work. This work was supported by USPHS grant DE13223 and NASA NAG 2-1585 to M.B.-F.Additional details
- Eprint ID
- 64099
- DOI
- 10.1016/j.devcel.2004.08.007
- Resolver ID
- CaltechAUTHORS:20160129-132837174
- NIH
- DE13223
- NASA
- NAG 2-1585
- Created
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2016-01-29Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field