Published May 31, 1972
| public
Journal Article
Multiple Length DNA Molecules of Bacteriophage φX174
- Creators
- Benbow, R. M.
- Eisenberg, M.
- Sinsheimer, R. L.
Abstract
Rush and Warner have suggested that circular double length DNA molecules of bacteriophage S13 arise during genetic recombination, presumably in a single reciprocal recombination event between two monomeric circles. In other systems, however, circular molecules of multiple length are produced by errors in replication. We now demonstrate that most circular multiple length DNA molecules of bacteriophage φX174 arise by replication and that, moreover, some catenated DNA molecules contain interlocked rings of two different parental types.
Additional Information
© 1972 Nature Publishing Group. Received December 6, 1971; revised February 14, 1972. We thank Drs Paul Howard-Flanders and Philip Sharp for suggestions and Mrs J. S. Kim for the plates in Fig. 2. This research was supported by a grant from the US Public Health Service. R. B. is supported by a National Institutes of Health training grant, and M. E. by a fellowship from the Rockefeller Foundation.Additional details
- Eprint ID
- 64015
- Resolver ID
- CaltechAUTHORS:20160127-115432856
- U.S. Public Health Service (USPHS)
- NIH
- Rockefeller Foundation
- Created
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2016-01-27Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field