A crystalline platinum blue: its molecular structure, chemical reactivity, and possible relevance to the mode of action of antitumor platinum drugs

Abstract

The simple inorganic complex cis-dichlorodiammineplatinum (II) (DDP) inhibits the division of bacterial cells with little effect on their growth. It was subsequently shown that DDP has substantial antitumor activity on a wide variety of animal malignancies. These findings stimulated numerous investigations of diammineplatinum (II) complexes both to establish their mode of action and to design more effective antitumor platinum drugs.

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