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Published September 1978 | public
Journal Article

A crystalline platinum blue: its molecular structure, chemical reactivity, and possible relevance to the mode of action of antitumor platinum drugs

Abstract

The simple inorganic complex cis-dichlorodiammineplatinum (II) (DDP) inhibits the division of bacterial cells with little effect on their growth. It was subsequently shown that DDP has substantial antitumor activity on a wide variety of animal malignancies. These findings stimulated numerous investigations of diammineplatinum (II) complexes both to establish their mode of action and to design more effective antitumor platinum drugs.

Additional Information

© 1978 New York Academy of Sciences. Manuscript received July 11, 1977. Supported by National Institutes of Health Research Grant no. CA-15826 from the National Cancer Institute. J.K.B. is the recipient of a Predoctoral Fellowship from the National Science Foundation. We are grateful to Engelhard Industries for generous loans of K_2PtCl_4.

Additional details

Created:
August 19, 2023
Modified:
October 17, 2023