Published March 10, 1999
| public
Book Section - Chapter
Radical migration through the DNA helix: chemistry at a distance
- Creators
-
Kelley, Shana O.
-
Barton, Jacqueline K.
- Others:
- Sigel, Astrid
- Sigel, Helmut
Abstract
The reaction of the DNA bases with radical species generated by radiation, carcinogens, or oxidative stress can lead to mutagenic damage [1]. The efficiency and dynamics of radical transport through the DNA helix therefore hold profound biological implications. Intriguing questions concerning charge migration through DNA arise that can now begin to be addressed through well-defined chemical experiments. Does radical migration through DNA occur over long molecular distances? How is it modulated by DNA sequence and the structural variations in DNA? Is it physiologically important? How general is this phenomenon? These are issues that need to be addressed in the context of delineating mechanisms of DNA damage and repair.
Additional Information
© 1999 Marcel Dekker. We are grateful to the National Institutes of Health and the National Foundation for Cancer Research for their financial support of this work. In addition, we thank our colleagues and collaborators, as referenced throughout the chapter, for their efforts and their ideas.Additional details
- Eprint ID
- 63955
- Resolver ID
- CaltechAUTHORS:20160125-201652834
- NIH
- National Foundation for Cancer Research
- Created
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2016-02-08Created from EPrint's datestamp field
- Updated
-
2019-10-03Created from EPrint's last_modified field
- Series Name
- Metal Ions in Biological Systems
- Series Volume or Issue Number
- 36