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Published November 2002 | public
Journal Article

Neural expression of mouse Noelin-1/2 and comparison with other vertebrates

Abstract

Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8–10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the cranial ganglia. Later, expression is prominent in brain tissue and in the zone of polarizing activity in the limb.

Additional Information

© 2002 Elsevier Science Ireland Ltd. Received 11 April 2002; received in revised form 31 May 2002; accepted 31 May 2002. The authors wish to thank Anne Knecht and Clare Baker for reading the manuscript and Meyer Barembaum for providing photographs of chick Noelin-1/2 expression for Fig. 4. T.A.M. is a Fellow of the ARCS foundation. This work was supported by grant NS42287 to M.B.-F.

Additional details

Created:
August 21, 2023
Modified:
October 17, 2023