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Published February 15, 1963 | public
Journal Article

N-Methylmetanephrine: Excretion by Juvenile Psychotics

Abstract

Three out of 18 psychotic children excreted N-methylmetanephrine, a metabolite of N-methylepinephrine. It is not clear whether this tertiary amine plays a part in causing some forms of psychosis or is merely a secondary result of mental dysfunction. Urinary excretion of bufotenin and of 3,4-dimethoxyphenylethylamine, each of which has been reported elevated in some adult schizophrenics, was not unusual in these children.

Additional Information

© 1963 American Association for the Advancement of Science. 7 December 1962. Contribution No. 2903, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena. I thank Dr. Julius Axelrod of the National Institutes of Health for the N-methylmetanephrine, and Dr. Robert Simonds and Dr. Percy Minden of Los Angeles for help with three of the patients studied. Supported by grants from the Richard W. Lippman Memorial Fund and the National Institutes of Health.

Additional details

Created:
August 19, 2023
Modified:
October 25, 2023