Architecture and Assembly of Chemoreceptor Arrays as seen by Electron Cryotomography

Abstract

Most motile bacteria as well as many archaea sense and respond to their environment through arrays of chemoreceptors. While X-ray crystallography and NMR spectroscopy and other high-resolution structural methods have produced atomic models of components and sub-complexes of these arrays, we have used electron cryotomography to visualize their basic architecture in their native state within intact cells and reconstituted in vitro systems to ∼2 nm resolution, revealing principles of array structure and assembly.

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