Published 1970
| public
Journal Article
The stereochemistry of N-methyl-3-(P-fluoro-benzoyl)-4-hydroxy-4-(P-fluorophenyl)piperidine
Chicago
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Abstract
A rigorous assignment of the stereochemistry of substituted piperidines of the type 1 has not been reported. However, a paper by Unkovskii, et al., reporting infrared spectral studies of intramolecular hydrogen bonding in closely similar systems suggests that the bulky benzoyl and phenyl groups would be most energetically favored disposed in the trans-diequatorial configuration of the piperidine ring (chair form, 2). This evidence is, however, equivocal because such bonding is also possible in other conformations.
Additional Information
© 1970 Pergamon Press. Received in USA 24 August 1970; received in UK for publication 5 October 1970. The X-ray and nmr studies which were carried on at the California Institute of Technology were supported by the National Science Foundation. Contribution No. 4066.Additional details
- Eprint ID
- 61515
- Resolver ID
- CaltechAUTHORS:20151026-093704117
- NSF
- Created
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2015-10-26Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field
- Other Numbering System Name
- Caltech Gates and Crellin Laboratories of Chemistry
- Other Numbering System Identifier
- 4066