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Published February 1, 1981 | public
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Nitrogen-15 nuclear magnetic resonance spectroscopy of 5-azacytidine

Roberts, John D.
Sullivan, Glenn R.
Pang, Patty P.
Leonard, Nelson J.
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Abstract

5-Azacytidine (4-amino-1-β-D-ribofuranosyl-1,3,5-triazin- 2(1H)-one, 1) has been investigated for its potential in leukemia therapy, based on the finding, inter alia, that mRNA containing 5-azacytidylic acid residues is unable to function correctly in protein synthesis. The compound is also of interest for comparison of its ^(15)N NMR characteristics with those of cytidine (2), especially with regard to assignments of chemical shifts, differentiation between the N4' protons, degree of restricted rotation about C4N4', and site of protonation of the ribonucleoside.

Additional Information

© 1981 American Chemical Society. Received September 3, 1980. Supported at the California Institute of Technology by the U.S. Public Health Service, Research Grant No. GM 11072 from the Division of General Medical Sciences, and at the University of Illinois by the National Science Foundation, Research Grant No. CHE-7623543. Supported by National Science Foundation Undergraduate Research Participation Grant EPP 75-04744.

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August 19, 2023
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October 24, 2023