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Published October 25, 2007 | public
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Conformational Equilibria of Ethanolamine and Its Hydrochloride in Solution

Smith, Tim D.
Gerken, James B.
Jog, Parag V.
Roberts, John D.
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Abstract

The conformational preferences of ethanolamine and its hydrochloride in solution were estimated by comparing experimental NMR vicinal proton−proton coupling constants to semiemprical coupling constants for each staggered rotamer, derived by the Haasnoot−Altona method. Strong gauche preferences are observed for both ethanolamine and its hydrochloride over a wide range of solvent polarities. Concentration was not observed to significantly affect the position of the conformer equilibria.

Additional Information

© 2007 American Chemical Society. Received August 16, 2007. Publication Date (Web): October 2, 2007. Acknowledgment is made to the donors of the Petroleum Research Fund administered by the American Chemical Society for their support of this research. This material is also based upon work supported by the National Science Foundation under Grant No. CHE-0543620, the Summer Undergraduate Research Fellowship Program (SURF) at the California Institute of Technology as supported by the Howard Hughes Medical Institute, and the Senior Scientist Mentor Program of the Camille and Henry Dreyfus Foundation. In addition, we are indebted to Merck & Company, Dr. & Mrs. Chester M. McCloskey, Dr. David J. Mathre, and Edith M. Roberts for their helpful financial assistance. The authors thank Taylor Lenton for her generous assistance with the laboratory work at Caltech.

Additional details

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Created:
August 19, 2023
Modified:
October 24, 2023