Hierarchy of regulatory events in sensory placode development
Abstract
Cranial placodes are a uniquely vertebrate characteristic; they form the paired sense organs of the eyes, ears and nose, in addition to the distal parts of some of the cranial sensory ganglia. These focal ectodermal thickenings have been studied from an embryological perspective in a diversity of organisms, revealing tissue interactions that are crucial for the morphological formation of the different placodes. In recent times, there has been a renewed interest in understanding the induction and differentiation of these deceptively simple ectodermal regions. This has led to a wealth of information on the molecular cues governing these processes. In particular, the integration of signals at the level of 'placode-specific' enhancers is beginning to provide a glimpse into the complexity of genetic networks that function within this embryonic cell population to generate key components of the peripheral nervous system.
Additional Information
© 2004 Elsevier. This review comes from a themed issue on Differentiation and gene regulation. Edited by Michael G Rosenfeld and Christopher K Glass. We are very grateful to Drs. Andrea Streit, Andy Groves, Laura Gammill, Tatjana Sauka-Spengler and Subhabrata Sanyal for their advice and comments on the manuscript. We wish to apologize to those authors whose work we were unable to cite in this review because of space constraints. Supported by NIH grant DE 016459 to MBF. and a Howard Hughes predoctoral fellowship to SB.Additional details
- Eprint ID
- 59502
- DOI
- 10.1016/j.gde.2004.08.002
- Resolver ID
- CaltechAUTHORS:20150813-133336002
- DE016459
- NIH
- Howard Hughes Medical Institute (HHMI)
- Created
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2015-08-13Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field