Reticular Stimulation and Chlorpromazine

Creators: Phillips, M. I.; Bradley, P. B.; Kornetsky, C.; Eliasson, M.

Abstract

Based on the hypothesis that schizophrenics are overaroused as a result of long-term activation of the brainstem reticular formation (J), Kornetsky and Eliasson proposed that animals electrically stimulated in the reticular formation are overaroused in a similar fashion (2). They postulated an "inverted U" model in which overarousal moves subjects beyond an optimum level of performance and chlorpromazine keeps subjects before the optimum point; therefore the drug reduces the overarousal effects and produces improved performance.

Additional Information

© 1970 American Association for the Advancement of Science. Received 12 November 1969; revised 22 January 1970. Supported by the Medical Research Council of Great Britain. The experiments were carried out in the M.R.C. Neuropharmacology Research Unit. This comment was written while M.I.P. was supported by a PHS grant to Dr. J. Olds (GM-02031). We thank Dr. Olds for his support.

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Reticular Stimulation and Chlorpromazine

Abstract

Additional Information

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