Published August 21, 2015
| Accepted Version
Journal Article
Open
Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Cyclic Electrophiles
Abstract
This account describes our laboratory's efforts in the development of a palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic conjugate acceptors. Specifically, we highlight the study of this transformation in the following areas: (a) construction of all-carbon quaternary stereocenters, (b) elucidation of the reaction mechanism, (c) addition to heterocyclic acceptors to generate tertiary stereocenters, and (d) application in the synthesis of natural products.
Additional Information
© 2015 American Chemical Society. Received: May 28, 2015. Publication Date (Web): July 2, 2015. The authors thank the many past and present co-workers whose efforts have made our contributions in asymmetric conjugate addition possible: Michele Gatti, Emmett D. Goodman, Kotaro Kikushima, Bin Mao, Alexander N. Marziale, and Hideki Shimizu. Support for our program has been made available from the NIH-NIGMS (R01 GM080269), Amgen, and Caltech.Attached Files
Accepted Version - nihms789920.pdf
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Additional details
- PMCID
- PMC4896742
- Eprint ID
- 59024
- Resolver ID
- CaltechAUTHORS:20150728-085152188
- R01 GM080269
- NIH
- Amgen
- Caltech
- Created
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2015-07-28Created from EPrint's datestamp field
- Updated
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2022-05-26Created from EPrint's last_modified field