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Published April 1996 | public
Journal Article

Extending the recognition site of designed minor groove binding molecules

Abstract

A linked, imazole/pyrrole minor-groove ligand has been shown to bind sequence specificially to a 13 base-pair target sequence in a mixed 1:1/2:1 mode.

Additional Information

© 1996 Nature Publishing Group. Received 28 August 1995; Accepted 22 February 1996. B.H.G. and D.E.W. thank H.P. Spielmann, P.A. Fagan, T.D. Cole and R. Pelaez for helpful discussions. We are grateful to National Institutes of Health and the National Foundation for Cancer Research for research support, to the Ralph M. Parson Foundation for a graduate fellowship to M.M., and to the U.S. Department of Energy and National Science Foundation for instrumentation grants.

Additional details

Created:
August 20, 2023
Modified:
October 23, 2023